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Patients with sickle cell anemia (89.9%) and sickle- 0 -thalassemia were randomized to receive L-glutamine at 0.3 g/kg orally twice daily for 48 weeks followed by a three-week taper (136 exposed for six months, 109 exposed for at least a year) or placebo ( n = 111)

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10.1186/s40413-016-0112-5 30 ChanR.DuraikannuC.LipworthB

Cascone T, McKenzie JA, Mbofung RM, Punt S, Wang Z, Xu C, Williams LJ, Wang Z, Bristow CA, Carugo A, Peoples MD, Li L, Karpinets T, Huang L, Malu S, Creasy C, Leahey SE, Chen J, Chen Y, Pelicano H, Bernatchez C, Gopal YNV, Heffernan TP, Hu J, Wang J, Amaria RN, Garraway LA, Huang P, Yang P, Wistuba II, Woodman SE, Roszik J, Davis RE, Davies MA , Heymach JV, Hwu P, Peng W

J.NasirK.et al (2021)

A decrease in viability can be observed in 2 cell types, with fibroblasts reacting more sensitive than epithelial cells