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On day -6, mice were randomized into four groups (n = 12/group): vehicle (PBS), or MEDI4166 (3, 10 or 30 mg/kg)

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All cell lines were cultured in suspension using RPMI-1640 medium (Gibco) supplemented 10% FBS (New Zerum), under the condition of 37 C and 5% CO 2

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