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Missed doses should not be doubled
5.5 Severe Gastrointestinal Adverse Reactions DOCVARIABLE vault_nd_fcd34bb4-3cb3-473c-864a-ed4ae529f642 \* MERGEFORMAT Use of GLP-1 receptor agonists, including BYDUREON BCISE, has been associated with gastrointestinal adverse reactions, sometimes severe [see Adverse Reactions (6)]
But this is anecdotal, and selection bias, those willing to try a newer, less proven compound tend to be more experienced and disciplined, could account for better reported outcomes
Additionally, overexpression of both arginase isoforms reduces L-arginine availability (Li et al., 2001)
Cersosimo E, Triplitt C, Solis-Herrera C, Mandarino LJ, DeFronzo RA
doi:10.1016/j.fertnstert.2008.08.074
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