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[DOI] [PubMed] [Google Scholar] Nahar K, Hasanuzzaman M, Suzuki T, Fujita M

Crystal structure of the alkylated human enzyme

Aldabbous L, Abdul-Salam V, McKinnon T, Duluc L, Pepke-Zaba J, Southwood M, Ainscough AJ, Hadinnapola C, Wilkins MR, Toshner M, Wojciak-Stothard B (2016) Neutrophil extracellular traps promote angiogenesis: evidence from vascular pathology in pulmonary hypertension

Short History: Developed by Shionogi & AstraZeneca First approved: 2003 Discovery country: Japan / United Kingdom collaboration Designed as a high-potency synthetic statin with longer half-life #Rosuvastatin #Statins #Pharmacology #MedicineOfTheDay #PharmacyLife #ClinicalPharmacy #CardiovascularHealth #Cholesterol #Dyslipidemia #Pharmacist #RehanKhan #Rosuvastatin #Statins #HMGCoAReductaseInhibitors #LipidLoweringTherapy #Dyslipidemia #CholesterolManagement #CardiovascularPrevention #HeartHealth #Pharmacology #ClinicalPharmacy #PharmacyEducation #MedicineOfTheDay #365DaysChallenge #PharmacistLife #HealthcareProfessionals #DrugEducation #MedicalKnowledge #PharmacyStudents #EvidenceBasedMedicine To view or add a comment, sign in Rosuvastatin Drug Class: Statin (HMG-CoA Reductase Inhibitor) Lipid-lowering agent Indications / Uses: Hypercholesterolemia ( LDL-C) Mixed dyslipidemia Hypertriglyceridemia Prevention of cardiovascular events (MI, stroke) Familial hypercholesterolemia Mechanism of Action (MOA): Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis Cholesterol production in liver LDL cholesterol & triglycerides HDL cholesterol LDL receptor expression increased LDL clearance Dose: Usual starting: 1020 mg once daily Maintenance: 540 mg once daily Severe hypercholesterolemia: up to 40 mg/day Renal impairment: lower starting dose recommended Adverse Effects: Myalgia / muscle pain Elevated liver enzymes Headache Nausea Risk of rhabdomyolysis (rare) Slight increase in blood glucose Drug Interactions: Cyclosporine rosuvastatin levels Gemfibrozil risk of myopathy Warfarin anticoagulant effect Antacids (Al/Mg) absorption Protease inhibitors statin toxicity risk Contraindications: Active liver disease Pregnancy Breastfeeding Hypersensitivity Clinical Pearl: Rosuvastatin is one of the most potent statins with strong LDL-lowering ability and proven cardiovascular risk reduction, often effective at lower doses compared to other statins

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Meanwhile, Lilly is going to make trillions, and there are quite literally millions of Americans using compounded GLP-1 Join the conversation