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Maximizing strength conditioning and lean muscle mass would require a dosage of 200-300mcg up to three times daily, but higher dosages can also illicit higher side effect profiles (flushing, headache, nausea, lethargy) Extremely high dose can have an effect on adrenocorticotropic hormone (ACTH), cortisol, and prolactin, and cause water retention, tingling, & numbness in the hands/feet