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In these five phase-3 trials, the efficacy of various tirzepatide doses were compared to a placebo, a GLP-1 receptor agonist (1mg semaglutide), and two long-acting insulin analogs

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Chemico-Biol Interact 386:110788 Wenzel SE, Tyurina YY, Zhao J, St CC, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayr H, Kagan VE (2017) Pebp1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals