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Sadjadi R, Sullivan S, Grant N, Thomas SE, Doyle M, Hammond C, Duong R, Corre C, David W, Eichler F (2020) Clinical myopathy in patients with nephropathic cystinosis

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Unlike the simpler AHK tripeptide, the coordinated copper ion in AHK-Cu acts as a critical cofactor for enzymes involved in the cross-linking of collagen and elastin

While its been used on skin and hair for generations in some parts of the world (it was even one of Cleopatras favorites!), its only made its debut in commercial products in the US in the past few decades