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This information is key for identifying pathway-biased agonists that avoid beta-arrestin-mediated side effects (e.g., tolerance), thereby supporting lead optimization and selection of safer, more efficacious candidates before preclinical studies

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This prevents systemic inflammation by ensuring the gut barrier remains an effective filter against toxins

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La seleccin entre diferentes agonistas debe basarse en el perfil individual del paciente, considerando eficacia requerida, tolerabilidad y comorbilidades especficas