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The National Institute for Health and Care Excellence (NICE) provides guidance on obesity management in adults, including Technology Appraisal TA875 on semaglutide for managing overweight and obesity

Sep 2006;52(9):877-85

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However, these models have faced challenges in reproducing the wide range of symptoms observed in human HFpEF, since usually one organ system is targeted and the pathology is replicated in a relatively acute setting in comparison to the natural course of HFpEF in humans