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10.1016/j.ijbiomac.2022.05.199 227 NadaA

Patients should be informed about the signs of serious skin reactions, and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity Hypersensitivity/Anaphylaxis There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen

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Phenylalanine (Phe) Phenylalanine was first isolated from a natural source (lupine sprouts) in 1879 and subsequently synthesized chemically in 1882