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Unfortunately, it seems to be limited , or to quote a great article from the Journal of Cosmetic Dermatology "topically applied ascorbyl phosphate salts are, at very best, poorly absorbed in comparison with AA"

2021 Dec 1;12(8):1879-1897

The same has not been seen in people without a deficiency

Scientists studying metabolic pathways and NAD+ homeostasis have recognized 5-Amino-1MQ as a valuable probe for understanding how NNMT inhibition affects cellular function

doi: 10.2741/2765 301 NobleE

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