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Fatigue combined with cold intolerance and brain fog warrants measuring Free T3 rather than TSH alone. The obese trial cohorts lost roughly 8% of body weight at 1 mg in Phase 2 and about 28% at 12 mg in the 80-week Phase 3 trial

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Intrinsic factor production often decreases with aging

These factors contribute to better reproducibility in research and reduced variability in results

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