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You may also hear it called estradiol gel, estrogen gel, transdermal estrogen, or HRT gel

In published research it has been characterised as a triple agonist acting on the GLP-1, GIP and glucagon receptors

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Who is affected by opioids

Individuals under 18, pregnant or nursing individuals, or those with active medical conditions - per the brand's own label caution, physician consultation is recommended before use in these groups

Continuous use without cycling can lead to receptor desensitization, diminishing returns, and unknown long-term effects