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In vivo tests were then carried out on a hyperuricemic rat model, whose references for uric acid analysis were allopurinol and febuxostat

This lack of expression can be explained in light of previous mutagenesis studies which showed that some residues or sequences encompassed by TM5-L0 (chimera M1), ICL5-TM10-TM11 (chimera M4), TM14-TM15-ICL7 (chimera M7) are important for the correct addressing and folding of MRP1 19,34,46,47

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doi: 10.1001/jama.2017.6803