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Initially, NOX2 activation generates significant quantities of H 2 O 2 /O, which subsequently activate key signaling pathways such as MAPK and JNK, leading to nuclear membrane breakdown and chromatin decondensation, culminating in NET formation

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T-cells are one of the major white blood cell types involved in the adaptive immune system and migrate to the site of ischemic injury after the initial inflammatory cascade within 24 h (Jian et al., 2019) which is dependent on adhesion molecule expression in the endothelium (Shi et al., 2018)

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Proc Natl Acad Sci USA 97: 51015106 Tu BP, Weissman JS (2002) The FAD and O(2)dependent reaction cycle of Ero1mediated oxidative protein folding in the endoplasmic reticulum