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As mentioned above, one of the ways that cells can enter senescence is when their telomeres are shortened beyond usefulness the cell may (or may not) still be working well, but it has lost the ability to divide

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V., Vilsbll T., Rabl R., et al., Four Weeks of NearNormalisation of Blood Glucose Improves the Insulin Response to GlucagonLike Peptide1 and GlucoseDependent Insulinotropic Polypeptide in Patients With Type 2 Diabetes, Diabetologia 52, no