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Availability of data and materials The datasets used and analyzed in the present study are available from the corresponding author on reasonable request

This typically improves as treatment continues and should be discussed with your healthcare professional if persistent

While primers sequence for IL8, HSP27 and SOD1 were designed using Primer3 ( and Primer-BLAST ( Primer specificity was verified by running PCR for 40 cycles at 95 C for 10 seconds and 60 C for 60 seconds, followed by gel electrophoresis on a 3% agarose gel stained with SYBR safe DNA gel stain

doi: 10.1007/s00018-020-03574-z 49 de KoningTJ

Conversely, BAT is characterized by its ability to burn energy and produce heat, whereas it enriches mitochondria content and the action of uncoupling protein 1 (UCP-1), which helps in heat generation from fats

However, they may cause side effects, including decreased blood pressure, nausea, and vomiting