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Taking alpha-lipoic acid by mouth seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes

Efficacy and safety of intranasal peptide YY336 for weight reduction in obese adults

emphasize the value of combined therapy further by pointing out that when nutritional therapy and exercise therapy are combined, the results are better gains in muscle strength and gait speed than when either modality is used alone (151)

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Lindsey Yourman, associate clinical professor in the division of geriatrics, gerontology, and palliative care at the University of California San Diego School of Medicine