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Tumor cells respond to oxidative stress by altering the activity of antioxidant transcription factors, including HIF-1, essential for cellular redox homeostasis [72, 75]

NTS acts as a relay station for incoming information to the central automatic network (CAN), which includes key areas such as the hypothalamic paraventricular nucleus, locus coeruleus, brachiocephalic nucleus, and limbic system

doi: 10.1038/s41467-020-16026-w

Given the rich lipid content of the nervous system, hemoglobin-derived iron works with lipid peroxidation to induce ferroptosis, which eventually leads to neuronal mitochondrial damage, edema, and apoptosis of neurons and astrocytes

The night prior to our chat, he got about four hours of sleep, though he usually shoots for seven a night

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