It works as a triple agonist, activating GLP-1, GIP, and glucagon receptors simultaneously
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It is also essential to integrate biological markers (e.g., BDNF, IGF-1, VEGF, inflammatory cytokines) and neuroimaging measures (e.g., functional connectivity, hippocampal volume) into future studies, to better understand underlying mechanisms and personalize interventions
To improve outcomes, combining HDACis with immunotherapies or autophagy inhibitors is a promising direction
For others, alternative drugs to metformin may be preferable, but a person must discuss this change with a doctor before stopping metformin or altering their dose.