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Response: We acknowledge commenters' concern regarding the timing around measure removal and the costs of preparing to report on the measures

[Abstract] Food Sci Biotechnol

However, the further clinical development of pramlintide/metreleptin combination therapy has been discontinued by the manufacturing companies because of safety concerns [249](Table 3 )

A recent single-cell RNA-sequencing analysis showed that metformin increases the differentiation of neural stem cells and expands the population of neural stem cells and oligodendrocyte precursors in APP/PS1-AD mice (Qiu-Yue et al., 2022)

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135 Tirzepatide is developed by Eli Lilly and has proven to provide superior blood sugar control and significant weight loss, making it particularly valuable in the treatment of T2DM