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M., Lynch, B

Hepatotoxicity is the greatest concern associated with APAP treatment

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10.1073/pnas.2506321122 [DOI] [PMC free article] [PubMed] [Google Scholar] Tao Z., Le Blanc Justin M., Wang C., Zhan T., Zhuang H., Wang P., et al

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In addition to High-dose intravenous acetylcholine severe vasodilation and a profound drop in blood pressure, the high concentration of acetylcholine directly stimulates M2 muscarinic receptors in the sinoatrial (SA) node of the heart (Brown & Eccles, 1934)