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Moreover, GLP-1 and its analogs have shown positive effects in kidney protection, neuroprotection, and lipid metabolism regulation, and they hold promise in treating conditions like non-alcoholic steatohepatitis (NASH) and Alzheimer's disease
[64], which involved a co-culture of primary astrocytes with the bEnd.3 endothelial cell line, incubation with exendin-4 reduced the levels of the astrocyte-derived vascular endothelial growth factor (VEGF-A), matrix metalloproteinase-9 (MMP-9), chemokine monocyte chemoattractant protein-1 (MCP-1), and the chemokine C-X-C motif ligand 1 (CXCL-1), induced by oxygenglucose deprivation (OGD), and subsequently led to the increased expression of tight junction proteins in the bEnd.3 cells
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Mller et al., 2019)
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