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Approximately 2.2 million bone grafts are performed globally each year, ranking as the second most common tissue transplantation after blood transfusion (Sivakumar et al., 2022)

They are susceptible to degradation pathways that small molecules simply do not face, including deamidation, oxidation, aggregation, and hydrolysis

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Further, Eli Lilly could potentially see operating leverage as higher sales spread out the fixed costs of their operations, similar to what occurred with Viagra and Pfizer

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