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The HDAC inhibitor SAHA can induce the conversion of T cells into functional Tregs and alleviate pulmonary hypertension, confirming the central role of metabolic-epigenetic crosstalk in regulating T cell function ( In PH, the metabolic reprogramming of PASMCs and PAECs actively shapes the immune microenvironment through the release of specific metabolites

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The final cell suspensions were analyzed by flow cytometry to test the intensity of DCFH-DA fluorescence at excitation and emission wavelengths of 480 nm and 530 nm, respectively

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