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However, using an ECD-binding antibody Fab fragment (Fab7F38) for co-crystallization, we successfully crystallized the GLP-1RPF-06372222Fab7F38 complex

Further, to ensure exclusive treatment with GLP1 RA or metformin, we incorporated a 90day grace period from the date of the initial prescription to evaluate the prescriptions of other glucoselowering drugs, only including those who claimed solely their initial prescription or more of the initial treatment GLP1 RA within this period

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These are generally most pronounced during the dose titration phase and tend to diminish as the body adjusts to treatment