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Unlike many peptides that act through a single well-defined receptor, GHK-Cu exerts its biological effects through multiple mechanisms including direct stimulation of collagen and glycosaminoglycan synthesis, activation of antioxidant enzymes, modulation of metalloproteinase activity, promotion of angiogenesis, and broad regulation of gene expression across hundreds of genes involved in tissue repair, inflammation, and cellular protection
Nephrol Dial Transplant 23:991997 Mantovani G, Macci A, Madeddu C, Gramignano G, Serpe R, Massa E, Dess M, Tanca FM, Sanna E, Deiana L, Panzone F, Contu P, Floris C (2008) Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results
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