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When the body's detoxification pathways are compromised by this viral-induced oxidative stress, it loses its ability to effectively clear everyday environmental toxins
Funding This work was supported by the Projects of Medicine and Health Science Technology Development Program in Shandong Province [2016WS0499], Shandong Provincial Natural Science Foundation of China Grants [ZR2019PH025]
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In a molecular docking assay, it was further found that EGCG directly binds to the mouse KEAP1 protein by forming hydrogen bonds with specific residues within the KEAP1 protein, suggesting that NRF2 may play a key role in the protection of DN by EGCG through inhibition of the function of the KEAP1 protein
Cellular and molecular mechanisms of presynaptic assembly
