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Indirect evidence arises from a murine model of multiple sclerosis, in which sub-chronic administration of CBD (5 mg/kg/day for 7 days) significantly reduced the production of chemokines (CCL1,2) that act as key chemo-attractants for inflammatory cells within the CNS

This subgroup of patients represents a significant clinical challenge due to the complexity of the disease, often burdened by several different comorbidities

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Other contributing factors may include genetic predisposition, environmental triggers, or a combination of both