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The absolute risk increase is approximately 25 additional events per 10,000 person-years

This rapid turnover means that maintaining therapeutic levels of GLP-1 activity requires either continuous endogenous production or pharmaceutical intervention with DPP-4-resistant analogs

EClinicalMedicine 72 , 102624 (2024)

stable ~24 months

6 Emerging clinical applications 6.1 Non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD) Studies investigating GLP-1 receptor agonists for the prevention of NAFLD/NASH indicate potential effectiveness via several molecular mechanisms

5 Users have 4 times greater risk for stomach paralysis and bowel obstructions and 9 times greater risk for pancreatitis