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The medication must be titrated carefully because three receptor pathways mean three sets of biological effects to manage

In the short term, eating smaller portions may reduce sharp spikes and crashes in blood glucose, while over the long term, weight loss can improve insulin sensitivity

The non-enzymatic components include the major cellular redox buffers: ascorbate (AsA) and glutathione (-glutamyl-cysteinyl-glycine, GSH) as well as tocopherol, flavonoids, alkaloids, and carotenoids (Arora et al., 2000

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