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TTR was also detected at lower levels in the individuals with type 1 diabetes, and, of further relevance to the islet cells, the homo-tetramer of TTR has been reported in relation to the preservation beta cell integrity and secretion [44]

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By intersecting the above 163 targets with 111 targets in the PPI network, 3 key targets were identified, including adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and tyrosinase enzyme (TYR)

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