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Chronic, uninterrupted activation can lead to pathway desensitization, the biological equivalent of diminishing returns

Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

May help protect neurons from oxidative or inflammatory damage

We're talking about a compound that, in preclinical studies (mostly in animal models), has shown a remarkable ability to promote healing in a variety of tissuesfrom muscle and bone to ligaments and, yes, tendons

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