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Bibcode:1991BBRC..176..741P

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Key Takeaways: The 2025 Launch Pipeline The $29 billion aggregate forecast reflects a shift in the commercial center of gravity in pharma away from blockbuster mass-market drugs (where pricing pressure from PBMs, IRA negotiation, and international reference pricing compresses net revenues) toward rare and specialty biologics and first-in-class small molecules where the IP estate is durable, the payer negotiating position is stronger, and the per-patient economics justify the infrastructure investment

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It is important to note that fatigue is specifically listed as a common adverse reaction in clinical trials for Wegovy (occurring in 5% of patients)

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