Human-equivalent dosing extrapolated from animal studies suggests 200 to 500 micrograms per day, administered subcutaneously for musculoskeletal or systemic targets and orally for gut-specific applications
doi: 10.1515/bc.2006.166
Gently swirl until fully dissolved
It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
The most commonly reported effects are sexual: reduced libido, erectile dysfunction, and ejaculatory changes
All animal studies were performed according to the guidelines of the Chinese Council on Animal Care and were approved by the Affiliated Tumor Hospital of Guangxi Medical University Committees on Animal Experimentation (Nanning, China)
