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Importantly, we present current and emerging strategies aimed at restoring gutbrain communication, including dietary interventions such as fiber-rich and Mediterranean diets, SCFA supplementation, probiotics, and fecal microbiota transplantation (FMT)

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While roGFP2 WT was completely oxidized at even very low PfGrx C32S/C88S (SSG) concentrations, 1 M PfGrx C32S/C88S (SSG) glutathionylated approximately 50% of 1 M roGFP2 C151S (SH) suggesting that the redox couples roGFP2 C151S (SSG)/roGFP2 C151S (SH) and PfGrx C32S/C88S (SSG)/PfGrx C32S/C88S (SH) have very similar redox potentials

Inhibiting system Xc reduces GSH production, thereby diminishing the activity of GPX4 and leading to ROS accumulation, ultimately driving ferroptosis in CRC cells [61, 69-72]