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Both appear to be exacerbated by TNF inhibition and these agents are contraindicated in patients with a history of multiple sclerosis (MS), optic neuritis or uncontrolled CHF

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A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets

The researchers observed increases in several markers commonly associated with early nerve-cell development and proposed that Epithalon may act partly through epigenetic interactions with chromatin-associated proteins

Oxidative stress, free radicals, toxins and aging create issues with immunity and inflammation which in turn causes delayed healing, decreased metabolism, decreased recovery and disease

Key takeaway: Beyond fat burning, AOD-9604 may have broader metabolic effects