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cellular longevity

When B12 and Folate are deficient, adrenaline can pool in the synapses, contributing to the hyperadrenergic state and rapid heart rates frequently seen in POTS patients upon standing

Targeting HSPs in autoimmune diseases HSP90 inhibition and inflammatory control HSP90 inhibitors have shown notable immunomodulatory activity in preclinical autoimmune models, consistent with the role of HSP90 in stabilizing signaling proteins that amplify immune activation

The optimal administration route in humans has not been definitively established through clinical trials

Peer review Peer review information Nature Chemical Biology thanks Wen Yi and the other, anonymous reviewers for their contribution to the peer review of this work

Informed consents were obtained from the patients or their proxies and study was conducted according to protocols and methods approved by the local Institutional Review Board