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Exendin-4 has been shown to cross the blood-brain barrier (BBB) at high doses in mice [20], and exenatide demonstrates the fastest rates of brain influx compared to GLP-1 receptor agonists lixisenatide, liraglutide, and semaglutide [21]

The safety and pharmacokinetic characteristics of long-term local application of GLP-1RAs in human joints still need to be further evaluated, which is crucial for its transformation from the laboratory to the clinic

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For general educational context, the principles that apply to reconstituted lyophilised injectable medicines in regulated settings include: Refrigerated storage : Reconstituted solutions are typically stored at 28C unless the SmPC specifies otherwise