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Moreover, H 2 S induces sulfhydrylation of Kelch-like ECH-associated protein 1 (Keap1) at Cys151, promotes its association with (NF-E2)-related factor 2 (Nrf2), and increases the expression of Nrf2-associated antioxidant genes in vivo and in vitro, thereby improving liver function and reducing liver fibrosis

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