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For example, X-box binding protein 1 (XBP1), a transcription factor containing zinc finger structure, is critical for UPR signaling network and acts on the folding of multiple proteins regulated by downstream target molecules

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Herein, mh-Tyr-C3G complex was recognized with the most considerable free binding energy before ( 34.72 kcal/mol) and after ( 74.51 20.49 kcal/mol) against other bioactive compounds and positive inhibitors docked with mh-Tyr (Fig

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Nature Medicine In this Phase 2 trial, the triple agonist led to marked reductions in liver fat and improvements in metabolic parameters in participants with MASLD