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Long-term GLP-1 use (3+ years) is considered safe in clinical practice, with no new safety signals emerging in real-world data

Healthcare professionals should be aware that sleep disturbances reported by patients taking Mounjaro may be multifactorial, potentially related to the medication's metabolic effects, changes in eating patterns, weight loss itself, or coincidental factors rather than a direct pharmacological effect on sleep architecture or circadian rhythms

Xultophy: Epar - Product Information (2014)