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Incretin-based therapy may target the underlying metabolic and hormonal pathways that are thought to be involved in developing NAFLD

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This is due to several factors that differ between the controlled conditions of in vitro studies and the complex biological processes in living organisms, including interactions between different cell types, organ systems, and environmental variables (e.g., gut microbiota or circulation) that can influence how a drug works

It means the comparison usually favors ipamorelin when selectivity is important

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