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The work of Zhang and colleagues is important for physicians who treat diabetes because class B G protein-coupled receptors (GPCRs) are important therapeutic targets

But I know from my own experience as policy director of the Federal Trade Commission at the close of the Clinton administration that there is remarkable consistency between presidents

Implication of free radical mechanisms in ethanol-induced cellular injury

10.1172/JCI72434 [DOI] [PMC free article] [PubMed] [Google Scholar] Su, Z

By targeting Toll-like receptor-4 (TLR-4), resistin activates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) signaling to increase the expression of the macrophage inflammatory protein chemokine C-C motif ligand 4 (CCL4), thereby fostering macrophage infiltration into discs (47)

We do not fully understand how isolating that fragment changes its long-term interaction with the immune system