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In the STEP1 trial, semaglutide (2.4 mg) induced a mean weight loss of 14.9% among overweight or obese patients who did not have T2DM [68]

GSH mediates the regulation of redox-dependent pro-inflammatory cytokines, such as IL-9 and TNF- and also has vasodilator properties by increasing cyclic GMP levels and by contributing to the regeneration of endothelial-derived relaxing factor (EDRF), reducing the inflammatory state [27]

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