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doi: 10.1164/rccm.201005-0756OC 72 HaworthCSFowerakerJEWilkinsonPKenyonRFBiltonD

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Depending upon the grade of MVD, they found significant changes in gene expression intensity in especially ACTA2, HTR2B, MMP12 , and CDKN2A

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Rsearchers reported that metformin primarily ameliorates LH levels in lean patients with PCOS, whereas in obese patients with PCOS, its predominant effect lies in improving IR (Yang et al., 2018