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Patients should separate the timing of these medications and follow their healthcare provider's advice on appropriate dosing intervals

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Initially discovered in 1973 for its role in inhibiting gastric acid secretion in excised canine stomach pouches, and later shown to not have this effect in humans (Meier et al., 2004a), GIP promotes nutrient-stimulated insulin secretion and increases glucagon secretion in the fasted state but not in patients with type 2 diabetes ( The physiological concentrations of the peptide hormones GIP, GLP-1, and GLP-2, are tightly controlled by the nutrient-sensing abilities of their respective enteroendocrine cells

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Retatrutide brings the added benefit of glucagon receptor activation, which may lead to greater fat reduction and metabolic improvements