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In contrast to these reports, the acidic residues of p53 TAD were not critical for its interaction with the FOXO4 FHD (Table 1)

Studies, including those published as recently as late 2025, indicate that this mechanism can lead to a reduction in fat cell size and proliferation, alongside an increase in resting metabolic rate

The proposed use reviewed by the committee was much narrower than the claims commonly found on clinic websites