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doi: 10.1038/s41587-019-0209-9 32 CallahanBJMcMurdiePJRosenMJHanAWJohnsonAJHolmesSP

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3.1.4 The hippo and other ferroptosis-related pathway and RCC The knockdown of MIT domain-containing protein 1 down-regulates TAZ (a downstream signaling factor of the Hippo pathway) and causes the inhibition of SLC7A11 expression, thereby inhibiting cellular cysteine uptake and inducing ferroptosis (92)

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4) Cytoprotection & Tissue Integrity (Gastrointestinal Concept) Within Roberts cytoprotection/adaptive cytoprotection framework, BPC-157 has been discussed as a stable peptide with broad mucosal-protective properties in preclinical models (Sikiric 2019, review