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The second mechanism involves inhibition of clonogenic cell growth, potentially via downregulation of RRM2 and DNA damage, leading to accumulation of DNA breaks and cell cycle blockade

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Backert S, Boehm M, Wessler S, et al

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Healthcare professionals should conduct comprehensive assessments before initiating any treatment programme

One study demonstrated that aptamer d3 binding was revealed to block the MDR of the tumor cells and increase the accumulation of intracellular anticancer drug, which lead to a boost to the cell killing (101)